Steven N. Evans's A mutation-selection model with recombination for general PDF

By Steven N. Evans

ISBN-10: 0821875698

ISBN-13: 9780821875698

ISBN-10: 4400057283

ISBN-13: 9784400057284

The authors examine a continual time, chance measure-valued dynamical approach that describes the method of mutation-selection stability in a context the place the inhabitants is countless, there's infinitely many loci, and there are susceptible assumptions on selective charges. Their version arises after they comprise very basic recombination mechanisms into an past version of mutation and choice provided via Steinsaltz, Evans and Wachter in 2005 and take the relative power of mutation and choice to be small enough. The ensuing dynamical procedure is a movement of measures at the area of loci. each one such degree is the depth degree of a Poisson random degree at the area of loci: the issues of a realisation of the random degree list the set of loci at which the genotype of a uniformly selected person differs from a reference wild sort as a result of an accumulation of ancestral mutations. The authors' motivation for operating in this sort of basic surroundings is to supply a foundation for figuring out mutation-driven adjustments in age-specific demographic schedules that come up from the complicated interplay of many genes, and for that reason to strengthen a framework for realizing the evolution of getting older

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X≥0 Note that there are three possible cases. • If ν(M) < e−1 , then there are two equilibria, corresponding to the two distinct solutions of ce−c = ν(M). The equilibrium corresponding to the smaller c is attractive, while that corresponding to the larger c is unstable. • If ν(M) > e−1 , then there is no equilibrium. • If ν(M) = e−1 , then there is a single equilibrium, which is unstable. We are now in a position to give an example which previews the general approaches in the following sections.

For example, the case where ν is a multiple of Lebesgue measure on the positive reals is important for demographic applications. This section sketches how the dynamical system for such measures can be handled by viewing the state space of the dynamical system as a subset of L∞ (M, ζ) for a suitable reference measure ζ. 12. ¯ for the space of signed measures on M such that the trace on • Write H ¯ is equipped any bounded Borel set A ⊂ M belongs to H. The space H with the σ-field generated by the maps π → π(A) as A ranges over the bounded Borel subsets of M.

17 that the dynamical system started from the null state with these costs converges to a finite equilibrium ρ∗ in H+ . In other words, if there is a range of fertile ages over which all deleterious mutations reduce survival by at least some minimal amount, then selection keeps the total intensity from going to infinity provided ν(M) ≤ e−1 ξ. 17 cannot be readily applied to this setting, at least not with a constant function τ . However, in some cases we can give a direct proof that no equilibrium exists with finite total mass.

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A mutation-selection model with recombination for general genotypes by Steven N. Evans

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