By Mennatallah Ali
Style 2 diabetes mellitus (T2DM) is a prolonged, innovative metabolic illness characterised by way of continual hyperglycemia. even though its major physiological abnormalities are insulin resistance and impaired insulin secretion, the explicit underlying determinants of those metabolic defects stay doubtful. There are advanced interactions among genetic, epigenetic, environmental and behavioral elements that give a contribution to the advance of diabetes. Non-pharmacological and pharmacological interventions were used for diabetic administration. over the last few years, examine has began to specialise in using novel adjuvant medications as antioxidants and anti inflammatory medicinal drugs for higher administration, because it was once published that either oxidative tension and irritation play a serious position within the sickness pathogenesis. therefore, the advance of antidiabetic medications that could opposite insulin resistance is a possible healing aim. even supposing antidiabetic medicinal drugs can be potent in enhancing glycemic keep an eye on, they don't seem to be potent in completely fighting the development of pancreatic ß-cells harm mediated via power hyperglycemia-induced decline in intracellular antioxidants. accordingly, antioxidant and anti inflammatory treatment might be regarded as an accessory to the widely used oral antidiabetics
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Additional info for A new approach in Type 2 diabetes mellitus treatment: Evaluation of the beneficial effect of L-cysteine in the treatment of type 2 diabetes mellitus
NAC can scavenge ROS and increase depleted glutathione levels. Activation of redox-sensitive NF-țB in response to a variety of signals (IL1, TNF-Į and ROS) can be also inhibited by NAC. NAC can interfere with cell adhesion, smooth muscle cell proliferation, stability of rupture-prone atherosclerotic plaques in the cardiovascular system, reduce lung inflammation and prolong survival of transplants (148). Figure (9): Sources and actions of cysteine and glutathione (GSH) (115). 36 Figu ure (10): The rolee of serinne kinase activatioon in oxiidative sttressinduced iinsulin resistance aand the prrotective effect e of some s antioxidaants by preeserving thhe intracelllular redoox balancee(149).
Pharmacokinetics The pharmacokinetic properties of these compounds favored a rapid but short-lived insulin secretory effect that suited administration with meals to promote prandial insulin release. Repaglinide is almost completely and rapidly absorbed with peak plasma concentrations after about 1 hour. 7 hours (193). Taken about 15 minutes before a meal; repaglinide produces a prompt insulin response, which lasts about 3 hours, coinciding with the duration of meal digestion(183). Repaglinide may be more suitable than nateglinide in patients with moderate renal insufficiency, where metformin and some SUs are contraindicated (183, 192).
Within the context of diabetes mellitus, controversially data on selenium levels in biological fluids can be found. Lower, similar and even higher selenium levels were reported in diabetic patients with respect to healthy subjects (109). Zinc, magnesium and chromium are of special interest. Severe Zn deficiency is not frequent but concerns have been raised about Zn levels in diabetic patients. Some studies have reported Zn deficiency in type 2 diabetes, others failed to find significant differences with healthy subjects (110).
A new approach in Type 2 diabetes mellitus treatment: Evaluation of the beneficial effect of L-cysteine in the treatment of type 2 diabetes mellitus by Mennatallah Ali