Read e-book online Advances in Enzymology and Related Areas of Molecular PDF

By F. F. Nord

ISBN-10: 0470122714

ISBN-13: 9780470122716

ISBN-10: 0470124970

ISBN-13: 9780470124970

Advances in Enzymology and comparable parts of Molecular Biology is a seminal sequence within the box of biochemistry, delivering researchers entry to authoritative studies of the most recent discoveries in all parts of enzymology and molecular biology. those landmark volumes date again to 1941, supplying an unmatched view of the ancient improvement of enzymology. The sequence deals researchers the most recent realizing of enzymes, their mechanisms, reactions and evolution, roles in complicated organic procedure, and their program in either the laboratory and undefined. each one quantity within the sequence beneficial properties contributions by means of major pioneers and investigators within the box from around the globe. All articles are rigorously edited to make sure thoroughness, caliber, and clarity.

With its wide selection of themes and lengthy historic pedigree, Advances in Enzymology and similar components of Molecular Biology can be utilized not just by way of scholars and researchers in molecular biology, biochemistry, and enzymology, but additionally through any scientist attracted to the invention of an enzyme, its homes, and its purposes.


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Additional info for Advances in Enzymology and Related Areas of Molecular Biology, Volume 26

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This enzyme and certain other epimerases have been shown to require catalytic amounts of DPN, which sug- 42 VICTOR GINSBURG UDP-D-GLUCOSE UDP-D-GALACTOSE gests that the mechanism of inversion involves an oxidation and reduction a t the C-4 position (49). The presumed 4-keto intermediate. however, has not been detected, and is possibly tightly bound to the enzyme. Several mechanisms for the inversion have been proposed (cf. 47,49,210) including one in which the pyrimidine ring of the sugar nucleotide actually participates in the reaction (47,50).

Enzymes that incorporate D-mannose-1-P into nucleotides other than guanosine are not known but probably occur since another nucleotide, containing mannose, dTDP-D-mannose, has been reportcd to be naturally occurring in Streptomyces griseus (71). I n view of their wide distribution and their precursor relationship t o other sugar nucleotides, UDP-D-glucose and GDP-D-mannose appear to be central intermediates in the synthesis of many sac- 46 VICTOR GINSBURG charides. Known reactions of the two nucleotides are shown in Figure 3.

51. Kasperbauer, M. , Borthwick, H. A,, and Hendricks, S. , Botan. , in press. 52. Khudairi, A. , and Hamner, K. , 29, 251 (1954). 53. , Frost und Licht als beeinflussende Krafte bei der Samenkeimung, Suppl. 2, E. Ulmer, Stuttgart, 1920, 187 pp. 54. , in A. , Radiation Biology, Vol. 111, McGraw-Hill, New York, 1956, p. 1. 55. , Angew. ,'73,513 (1961). 56. Marker, R. , Wagner, R. , Ulshafer, P. , Wittbecker, E. P. , and Rurf, C. , J. Am. Chem. , 65, 1199 (1943). 57. Mayfield, D. , Lincoln, R. , Hutchins, R.

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Advances in Enzymology and Related Areas of Molecular Biology, Volume 26 by F. F. Nord

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