By Nozomu Mori, Inhee Mook-Jung
This booklet brings jointly the main up to date details on fresh examine result of prime laboratories on getting older technological know-how in East Asia, relatively in Japan, Korea, and Hong Kong. beginning with a finished assessment of assorted hypotheses on organic mechanisms of getting older by means of Dr. Sataro Goto, each one bankruptcy covers extensive facets of the newest findings in aging-related themes: centenarian reports and genome research of progeria, metabolic biochemistry and neurobiology, toughness controls in yeast and nematodes, oxidative rigidity and calorie restrict, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s illnesses, with extra capability healing ways to those age-related neurodegenerative illnesses. additionally incorporated, partially, is a precis and the results of a systematic dialogue discussion board known as the Asian getting older center for durability (AACL) that has been held every year alternating among Japan and Korea over the past decade. This booklet can function an invaluable source for locating acceptable collaborators within the components it covers. the objective readership is made from graduate scholars and researchers at universities, scientific and/or life-science colleges, and biomedical and pharmaceutical institutes.
Why does getting older exist? How will we age? How is every one organism’s lifespan decided? those are primary questions within the box. We might be nonetheless faraway from attaining a whole view of getting older mechanisms, yet this publication, Aging Mechanisms, bargains a great chance to familiarize yourself with the main up to date development within the biomedical study of getting older in Japan and Korea, the 2 best international locations for human longevity.
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Extra resources for Aging Mechanisms: Longevity, Metabolism, and Brain Aging
Gondo Department of Clinical Thanatology and Geriatric Behavioral Science, Osaka University, Suita, Tokyo, Japan © Springer Japan 2015 N. Mori, I. 1 Y. Arai et al. Introduction One of the most striking features of modern society is the steady increase in life expectancy, accompanied by the rapid growth of the “oldest old” population, such as centenarians, those who reach the age of 100 years (Oeppen and Vaupel 2002; Vaupel 2010). Centenarians are virtually delayed or even escaped from life threatening diseases such as cardiovascular disease or cancers until the very late life, thus provide models for healthy aging (Perls 1995).
Goto Grasso M, Piscopo P, Confaloni A, Denti MA (2014) Circulating miRNAs as biomarkers for neurodegenerative disorders. Molecules 19:6891–6910 Grune T, Catalgol B, Licht A, Ermak G, Pickering AM, Ngo JK et al (2011) HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. Free Radic Biol Med 51:1355–1364 Harley CB, Pollard JW, Chamberlain JW, Stanners CP, Goldstein S (1980) Protein synthetic errors do not increase during aging of cultured human fibroblasts.
In the first part of this review, we summarize functional and biomedical characteristics of centenarians mainly based on the results from the Tokyo Centenarian Study (TCS), an interdisciplinary research on the oldest old. We propose several hypotheses on human aging based on these findings. Centenarians are generally characterized by delayed onset of age-related diseases or disabilities into their 90s; however, upon reaching the age of 100 years, substantial evidence has demonstrated that frailty (Gondo et al.
Aging Mechanisms: Longevity, Metabolism, and Brain Aging by Nozomu Mori, Inhee Mook-Jung