By Bernard M. E. Moret (auth.), Aaron Darling, Jens Stoye (eds.)
This booklet constitutes the refereed lawsuits of the thirteenth foreign Workshop on Algorithms in Bioinformatics, WABI 2013, held in Sophia Antipolis, France, in September 2013. WABI 2013 is one in every of seven workshops which, in addition to the eu Symposium on Algorithms (ESA), represent the ALGO annual assembly and highlights study in algorithmic paintings for bioinformatics, computational biology and platforms biology. The objective is to provide fresh learn effects, together with major work-in-progress, and to spot and discover instructions of destiny learn. The 27 complete papers provided have been rigorously reviewed and chosen from sixty one submissions. The papers disguise all features of algorithms in bioinformatics, computational biology and platforms biology.
Read Online or Download Algorithms in Bioinformatics: 13th International Workshop, WABI 2013, Sophia Antipolis, France, September 2-4, 2013. Proceedings PDF
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Additional resources for Algorithms in Bioinformatics: 13th International Workshop, WABI 2013, Sophia Antipolis, France, September 2-4, 2013. Proceedings
We show that the MKL networks are signiﬁcantly enriched with respect to the related biological processes and allow obtaining of novel insights on the modeled processes. We further compare MKL with an extant method, ANAT , demonstrating the power of our algorithm in integrating data from multiple conditions in a compact and informative manner. For lack of space, some algorithmic details are omitted or deferred to an Appendix. 2 Preliminaries Let G = (V, E) be a directed graph, representing a protein-protein interaction (PPI) network, with vertex set V and edge set E.
AM was supported in part by a fellowship from the Edmond J. Safra Center for Bioinformatics at Tel Aviv University. RS was supported by a research grant from the Israel Science Foundation (grant no. 241/11). References 1. : BioNet an R-package for the functional analysis of biological networks. Bioinformatics 26, 1129–1130 (2010) 2. : Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks. Sci. Signal. 2(81), ra40 (2009) 3. : Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.
Export from the ER is executed by so called COPII vesicles that bud from ER exit sites (ERES). A protein that is of central importance for ERES biogenesis and maintenance is Sec16A, a large (˜250 kDa) protein that localizes to ERES and interacts with COPII components . We have recently performed a siRNA screen to test for kinases and phosphatases that regulate the functional organization of the early secretory pathway . Among the hits identiﬁed were 64 kinases/phosphatases that when depleted result in a reduction in the number of ERES.
Algorithms in Bioinformatics: 13th International Workshop, WABI 2013, Sophia Antipolis, France, September 2-4, 2013. Proceedings by Bernard M. E. Moret (auth.), Aaron Darling, Jens Stoye (eds.)