Allergy and Tissue Metabolism - download pdf or read online

By W. G. Smith

ISBN-10: 1483200353

ISBN-13: 9781483200354

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Example text

It is still too early, however, to assess the significance of these observations in relation to the well documented sequence of events which occur in inflammation of non-allergic origin. The combination of antigen with antibody fixed in tissue is believed to cause tissue damage 43 The connective tissue mast cells and blood eosinophils and it is not difficult to envisage considerable morphological disruption occurring in cells simultaneously with the formation of a poly-macromolecular structure of the size of an antigen-antibody complex.

Chapter IV Histamine Histamine (C 5 H 9 N 3 molecular weight = 111) is chemically (see Fig. 1) 2-(4-imidazolyl)-ethylamine. The free base has a melting point of 83° C. It is freely soluble in water, ethyl alcohol and hot chloroform, but insoluble in diethyl ether. It forms a number of salts, of which the most common are the dihydrochloride and the acid phosphate. Histamine dihydrochloride (C 5 H 9 N 3 . 2HC1 molecular weight = 184) has a melting point of 245° C and is freely soluble in water, methanol and ethanol.

The same is true of the local anaphylactic reactions of rat uterus and rat skin. In the mouse it is likely but not yet conclusively established that serotonin is a chemical mediator of anaphylaxis in the whole animal and also the anaphylactic contraction of uterus. Related to the evidence summarised above is the difficulty of deciding in a given species whether anaphylotoxin plays any part in the anaphylactic reaction of the whole animal. This involves determining the relative involvement of reactions of antigen with fixed tissue antibody and the reactions between antigen and antibody circulating in the blood.

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Allergy and Tissue Metabolism by W. G. Smith

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